How it Works: Apoquel®
Watch the video to learn how Apoquel (oclacitinib tablet) selectively inhibits JAK enzymes within cells to stop the continuous cycle of itch and inflammation in dogs.
Apoquel is specifically designed to target the pathways that result in the sensation of itch and the inflammation associated with allergic conditions, regardless of the cause, such as flea allergy or contact allergy.
Apoquel works at itch neurons within the skin, preventing the transmission of the itch signal to the brain and the subsequent scratching behavior. Apoquel also stops the signals that promote the infiltration of inflammatory cells into the dermis, resulting in a decrease in the inflammation and redness of the skin associated with allergic disease.
Owners of itchy dogs treated with Apoquel reported a significant decrease in their dogs' itching four hours after giving Apoquel and a sustained improvement of skin lesions within four weeks.1,2
Watch the video below to learn more about how Apoquel inhibits JAK enzymes to stop the continuous cycle of itch and inflammation.
INDICATIONS: Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.
IMPORTANT SAFETY INFORMATION: Do not use Apoquel in dogs less than 12 months of age or those with serious infections. Apoquel may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval. Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. Apoquel has been used safely with many common medications including parasiticides, antibiotics and vaccines. See full Prescribing Information at Apoquelpi.com.
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References
1 Gadeyne C, Little P, King VL, et al. Efficacy of oclacitinib (Apoquel®) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Vet Dermatol. 2014;25(6):512-e86. doi:10.1111/vde.12166
2 Data on file, Study No. A161R-AU-12-096, Zoetis Inc.